Multiple loci in silico mapping in inbred lines
نویسندگان
چکیده
منابع مشابه
Bayesian multiple quantitative trait loci mapping for recombinant inbred intercrosses.
The Collaborative Cross (CC) is a renewable mouse resource that mimics the genetic diversity in humans. The recombinant inbred intercrosses (RIX) generated from CC recombinant inbred (RI) lines share similar genetic structures to those of F(2) individuals. In contrast to F(2) mice, genotypes of RIX can be inferred from the genotypes of their RI parents and can be produced repeatedly. Also, RIX ...
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Most current statistical methods developed for mapping quantitative trait loci (QTL) based on inbred line designs apply to crosses from two inbred lines. Analysis of QTL in these crosses is restricted by the parental genetic differences between lines. Crosses from multiple inbred lines or multiple families are common in plant and animal breeding programmes, and can be used to increase the effic...
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While the machinery of quantitative genetics can blissfully function in complete ignorance of any of the underlying genetic details, we are certainly interested (at least one some level) on the genetic basis of trait variation. At the most practical level, if a gene of major effect is segregating in our population of interest, we would certainly like to not only to be aware of this, but also to...
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An inbred strain survey is an essential first step to serious genetic analysis of a complex, quantitative trait. Thus, the ability to use mean phenotypic values from inbred strains to map likely genomic locations of quantitative trait loci (QTLs) “in silico,” as recently proposed by Grupe et al. (1), in theory constitutes a major advance, although mapping techniques based on fixed genotypes (e....
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ژورنال
عنوان ژورنال: Heredity
سال: 2009
ISSN: 0018-067X,1365-2540
DOI: 10.1038/hdy.2009.66